반응식
[CH2:1]([N:6]1[CH:10]=[C:9]([C:11](=[O:16])[CH2:12][CH:13]([CH3:15])[CH3:14])[CH:8]=[C:7]1[C:17]([C:19]1[CH:20]=[CH:21][C:22]([O:35][CH2:36][CH2:37][CH:38]([CH3:40])[CH3:39])=[C:23]([CH2:25][CH2:26][C:27]([O:29]CCC(C)C)=[O:28])[CH:24]=1)=[O:18])[CH2:2][CH:3]([CH3:5])[CH3:4].[OH-].[Na+].O.Cl>C(O)C.C(Cl)(Cl)Cl>[CH2:1]([N:6]1[CH:10]=[C:9]([C:11](=[O:16])[CH2:12][CH:13]([CH3:15])[CH3:14])[CH:8]=[C:7]1[C:17]([C:19]1[CH:20]=[CH:21][C:22]([O:35][CH2:36][CH2:37][CH:38]([CH3:40])[CH3:39])=[C:23]([CH2:25][CH2:26][C:27]([OH:29])=[O:28])[CH:24]=1)=[O:18])[CH2:2][CH:3]([CH3:5])[CH3:4]참가 물질
반응물 4
생성물 1
시약·촉매·용매 2
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of 0.67 g of isopentyl 3-[5-{[1-isopentyl-4-(3-methylbutanoyl)-1H-pyrrol-2-yl]carbonyl}-2-(isopentyloxy)phenyl]propanoate in 14 ml of ethanol is added 3.6 ml of 1 mol/L sodium hydroxide solution. The mixture thus obtained is stirred at 50° C. for one hour. Water and chloroform are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. Thus, 0.56 g of 3-[5-{[1-isopentyl-4-(3-methylbutanoyl)-1H-pyrrol-2-yl]carbonyl}-2-(isopentyloxy)phenyl]propanoic acid is obtained as a white solid product.
후처리
- customThe mixture thus obtained
- customthe organic layer is separated
- washThe organic layer is washed with water and saturated aqueous solution of sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- distillationthe solvent is distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-2ac770576048451a91238498c7e32575
- 출처 데이터셋
- uspto-grants-2008_01
- 특허 번호
- US07314888B1
연결된 노트
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