Hydrochloric Acid → 3,5-Diisobutoxybenzoic acid

HRID 2249684노트

반응식

HRID 2249684 반응식
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:16]=[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])[CH:18]=1)[C:9]([O:11]CC(C)C)=[O:10])[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].C(Cl)(Cl)Cl.Cl>CO.O>[CH2:20]([O:19][C:17]1[CH:16]=[C:8]([CH:7]=[C:6]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH:18]=1)[C:9]([OH:11])=[O:10])[CH:21]([CH3:23])[CH3:22]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 17816465Isobutyl 3,5-diisobutoxybenzoate

생성물 1

HCID 178165213,5-Diisobutoxybenzoic acid수율 87.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

In 13 ml of methanol is dissolved 2.5 g of isobutyl 3,5-diisobutoxybenzoate, to which is then added 2.3 ml of 5 mol/L sodium hydroxide solution. The mixture thus obtained is stirred at 50° C. for 3 hours. Chloroform and water are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and then the solvent is distilled off under reduced pressure. Thus, 1.8 g of 3,5-diisobutoxybenzoic acid is obtained as a white solid product.

후처리

  1. customThe mixture thus obtained
  2. customthe organic layer is separated
  3. washThe organic layer is washed with water and saturated aqueous solution of sodium chloride successively
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-de732816561e4a21a0495977400ad866
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07314888B1

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