Hydrochloric Acid → HCID 9944111, 화합물

HRID 2253350노트

반응식

HRID 2253350 반응식
[BH4-].[Na+].[CH3:3][C:4]([O:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[CH3:24])([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1)=[O:6].Cl>[OH-].[Na+].CO>[CH3:14][C:4]([O:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[CH3:24])([CH3:3])[CH:5]([C:7]1[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=1)[OH:6]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 9879261HCID 9879261, 화합물

생성물 1

HCID 9944111HCID 9944111, 화합물수율 100%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
35 °C

실험 절차

A solution of sodium borohydride (25.7 g) in 0.1N NaOH (202 mL) was added dropwise to a suspension of 2-methyl-1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)-1-propanone (251.9 g) in methanol (2519 mL). The mixture was stirred at 35° C. for 3 hours. After the mixture was adjusted to pH 7 by addition of 1N HCl under ice-cooling, methanol was distilled off, followed by extraction with toluene (2015 mL). The extract was washed, and the solvent was distilled off to quantitatively obtain the title compound as an oil (253.7 g).

후처리

  1. temperaturecooling
  2. distillationmethanol was distilled off
  3. extractionfollowed by extraction with toluene (2015 mL)
  4. washThe extract was washed
  5. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-b02c06dabc7e4312a821568f664a0689
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07323577B2

반응 노트

불러오는 중…