Iodine → 5,5-Dimethyl-1-iodo-trans-octen-3-ol

HRID 225362

반응식

HRID 225362 반응식
[CH3:1][C:2]([CH3:17])([CH2:14][CH2:15][CH3:16])[CH2:3][CH:4]([O:7]C1CCCCO1)[C:5]#[CH:6].C(BC(C(C)C)C)(C(C)C)C.C[N+]([O-])(C)C.[OH-].[Na+].[I:36]I.O1CCCC1CC(O)=O.O>COCCOCCOC>[CH3:1][C:2]([CH3:17])([CH2:14][CH2:15][CH3:16])[CH2:3][CH:4]([OH:7])/[CH:5]=[CH:6]/[I:36]

참가 물질

8

반응물 6

HCID 807IodineHCID 1145Trimethylamine oxideHCID 14798Sodium HydroxideHCID 192733Bis(1,2-dimethylpropyl)boraneHCID 538897305,5-Dimethyl-3-tetrahydropyranyloxy-1-octyneHCID 86732972Tetrahydrofuranacetic acid water

생성물 1

HCID 204656065,5-Dimethyl-1-iodo-trans-octen-3-ol

시약·촉매·용매 1

HCID 8150Diglyme용매

실험 절차

Treatment of 23.8 g. (0.100 mole) of 5,5-dimethyl-3-tetrahydropyranyloxy-1-octyne (Example 154) successively with 233 mg. of 0.43M disiamylborane in diglyme, 22.5 g. of trimethylamine oxide, 150 ml. of 1N sodium hydroxide, 25.4 g. of iodine, and 900 ml. of 3:1:1 tetrahydrofuran-acetic acid-water as described in Example 151 gives the title compound.

출처 및 근거

ORD 기록
ord-659265b1752e4f169bc2cc6c9755395b
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236027

연결된 노트

불러오는 중…