Phenylacetyl chloride → 2-Acetyl-3-oxo-4-phenyl-butyric acid methyl ester

HRID 2279640노트

반응식

HRID 2279640 반응식
[OH-].[Na+].[CH3:3][C:4]([CH2:6][C:7]([O:9][CH3:10])=[O:8])=[O:5].[C:11]1([CH2:17][C:18](Cl)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[CH3:10][O:9][C:7](=[O:8])[CH:6]([C:4](=[O:5])[CH3:3])[C:18](=[O:19])[CH2:17][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 7679Phenylacetyl chlorideHCID 7757Methyl acetoacetateHCID 14798Sodium Hydroxide

생성물 1

HCID 595798522-Acetyl-3-oxo-4-phenyl-butyric acid methyl ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

NaOH (10 N, 4.4 mL, 44 mmol) in H2O is added to a solution of MeCOCH2COOMe (5 g, 43.1 mmol) in THE at RT. PhCH2COCl is added dropwise to the mixture and the mixture is stirred for 14 h. The mixture is extracted with EtOAc (2×30 mL). The organic phase is dried. The product is purified by silica gel column chromatography using 3-5% EtOAc in hexane to afford the title compound.

후처리

  1. extractionThe mixture is extracted with EtOAc (2×30 mL)
  2. customThe organic phase is dried
  3. customThe product is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-6fe6ffc40f134228a75776eaf7723a58
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133204B2

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