Hydrochloric Acid → 2-(Piperidin-4-yloxy)pyrimidine hydrochloride

HRID 22955

반응식

HRID 22955 반응식
[H-].[Na+].C(OC(N1CCC(O)CC1)=O)(C)(C)C.[Cl:17]C1N=CC=CN=1.C(OC([N:31]1[CH2:36][CH2:35][CH:34]([O:37][C:38]2[N:43]=[CH:42][CH:41]=[CH:40][N:39]=2)[CH2:33][CH2:32]1)=O)(C)(C)C.Cl>CS(C)=O.O1CCCC1>[ClH:17].[N:39]1[CH:40]=[CH:41][CH:42]=[N:43][C:38]=1[O:37][CH:34]1[CH2:35][CH2:36][NH:31][CH2:32][CH2:33]1

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 744042-ChloropyrimidineHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 22591437Tert-butyl 4-(pyrimidin-2-yloxy)piperidine-1-carboxylate

생성물 1

HCID 225914382-(Piperidin-4-yloxy)pyrimidine hydrochloride

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8028Tetrahydrofuran용매

실험 절차

60% Sodium hydride (0.232 g) was gradually added to a tetrahydrofuran (4.5 ml) solution containing 1-tert-butoxycarbonyl-4-hydroxypiperidine (0.900 g) and 2-chloropyrimidine (0.666 g), and 2 hours later, dimethyl sulfoxide (1.0 ml) was added thereto, and the mixture was stirred at room temperature for 1 day to undergo reaction, thereby obtaining 1-tert-butoxycarbonyl-4-(2-pyrimidinyloxy)piperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(2-pyrimidinyloxy)piperidine.hydrochloride.

후처리

  1. customreaction

출처 및 근거

ORD 기록
ord-ba1830e01ff047e88529e7be4820093b
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849622B2

연결된 노트

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