Water → 1-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one

HRID 234493

반응식

HRID 234493 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[C:17](OC(=O)C)(=[O:19])[CH3:18].O>C(Cl)(Cl)Cl>[C:17]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1)(=[O:19])[CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 10328Indoline

생성물 1

HCID 276731-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one

시약·촉매·용매 1

HCID 6212Chloroform용매3회

실험 절차

A solution of 11.9 g of indoline in 100 ml of chloroform is cooled to 0° C., 13.9 ml of triethylamine are added and a solution of 10.4 ml of acetic anhydride in 10 ml of chloroform is then added dropwise, followed by 0.1 g of 4-dimethylaminopyride. After stirring for two hours at RT, water is added to the reaction mixture, extraction is carried out with chloroform, the organic phase is dried over sodium sulfate and the solvent is evaporated off under vacuum to give 15.44 g of the expected product, which is used as such.

후처리

  1. dry with materialthe organic phase is dried over sodium sulfate
  2. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-f6e181a0f676489494226c2a8c4f58a6
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594023

연결된 노트

불러오는 중…