Sodium Hydroxide → 7-Fluoro-2,3-dihydro-1H-indole

HRID 2353458

반응식

HRID 2353458 반응식
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.C([BH3-])#N.[Na+].[OH-].[Na+]>C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH2:8][CH2:7]2

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 27745047-Fluoro-1H-indoleHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 167682617-Fluoro-2,3-dihydro-1H-indole수율 54.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

7-fluoroindole (2.0 g, 14.8 mmol) was dissolved in acetic acid (6 mL) and sodium cyanoborohydride (1.87 g, 29.6 mmol) was added in 5 portions. The mixture was stirred for 1 hour then poured into 150 mL of 2N NaOH. The mixture was extracted with methylene chloride. The organics were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated to give 7-fluoroindoline (1.1 g).

후처리

  1. extractionThe mixture was extracted with methylene chloride
  2. washwashed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-74bf08cac423424aa246f19a619d4605
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750038B2

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