반응식
[CH3:1][C:2]1([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])[S:6][CH2:5][CH2:4][S:3]1.[C:13](=O)([O:16]C)[O:14][CH3:15].[H-].[Na+].Cl.[Cl-].[Na+]>O1CCCC1>[CH3:12][O:11][C:9](=[O:10])[CH:8]([CH2:7][C:2]1([CH3:1])[S:3][CH2:4][CH2:5][S:6]1)[C:13]([O:14][CH3:15])=[O:16]참가 물질
실험 절차
A mixture of about 160 g of methyl 2-methyl-1,3-dithiolane-2-propanoate, about 174.63 g of dimethyl carbonate, about 74.41 g of sodium hydride and about 1000 ml of tetrahydrofuran was refluxed for about 19 hours under argon. The mixture was cooled to room temperature, added to a mixture of ice and dilute hydrochloric acid (about 1N) with stirring and saturated with sodium chloride. The organic layer was washed with saturated sodium bicarbonate then saturated sodium chloride, dried and the solvent removed. The residue was dissolved in ether, treated with charcoal, filtered through silica gel and the solvent removed. The residue was distilled via a Kugelrohr collecting the major fraction at about 180°-190° C., at about 0.5 mm giving about 96.26 g of the desired title product as a yellow oil.
후처리
- temperaturewas refluxed for about 19 hours under argon
- washThe organic layer was washed with saturated sodium bicarbonate
- dry with materialsaturated sodium chloride, dried
- customthe solvent removed
- dissolutionThe residue was dissolved in ether
- additiontreated with charcoal
- filtrationfiltered through silica gel
- customthe solvent removed
- distillationThe residue was distilled via a Kugelrohr
- customcollecting the major fraction at about 180°-190° C.
출처 및 근거
- ORD 기록
- ord-8ebaee04aedf42ffb0c31d2e025e4f2c
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04640913
연결된 노트
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