Hydrochloric Acid → 2-(3-Methoxyphenyl)cyclopropane-1-carboxylic acid

HRID 2358448

반응식

HRID 2358448 반응식
C([O:3][C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:5])C.Cl>CCO.[OH-].[Na+]>[CH3:16][O:15][C:11]1[CH:10]=[C:9]([CH:7]2[CH2:8][CH:6]2[C:4]([OH:5])=[O:3])[CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 19358490Cyclopropanecarboxylic acid, 2-(3-methoxyphenyl)-, ethyl ester

생성물 1

HCID 139722332-(3-Methoxyphenyl)cyclopropane-1-carboxylic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

The crude 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester is dissolved in 30 ml EtOH and 15 ml 1N NaOH. After stirring over night, the reaction mixture is acidified with 1N HCl and extracted with diethyl ether. After removal of the solvent 7.1 g of the 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is obtained. This 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is used without further purification.

후처리

  1. extractionextracted with diethyl ether
  2. customAfter removal of the solvent 7.1 g of the 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid
  3. customis obtained
  4. customThis 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is used without further purification

출처 및 근거

ORD 기록
ord-115159adedc34e79819ccca64391392a
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763728B2

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