Ethyl 3-oxo-2-(2-phenylethyl)butanoate → 5-(2-Phenylethyl)-6-methyl-2-thiouracil

HRID 237064

반응식

HRID 237064 반응식
[C:1]1([CH2:7][CH2:8][CH:9]([C:15]([CH3:17])=O)[C:10](OCC)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][C:19]([NH2:21])=[S:20].[O-]CC.[Na+].[Na]>C(O)C>[C:1]1([CH2:7][CH2:8][C:9]2[C:10](=[O:11])[NH:18][C:19](=[S:20])[NH:21][C:15]=2[CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 219459Ethyl 3-oxo-2-(2-phenylethyl)butanoateHCID 2723790ThioureaHCID 2723922Sodium ethoxideHCID 5360545Sodium

생성물 1

HCID 129459705-(2-Phenylethyl)-6-methyl-2-thiouracil

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl α-(phenylethyl)acetoacetate (23.4 g) and thiourea (10.65 g) were added to a solution of sodium ethoxide in ethanol (100 ml) prepared from sodium (4.6 g). The mixture was refluxed for 51/2 hours and evaporated to dryness. The solid residue was dissolved in water and acetic acid was added to pH 4. The white precipitate was filtered off and recrystallised from ethanol to give 5-(2-phenylethyl)-6-methyl-2-thiouracil m.p. 210°-214°.

후처리

  1. temperatureThe mixture was refluxed for 51/2 hours
  2. customevaporated to dryness
  3. dissolutionThe solid residue was dissolved in water
  4. additionacetic acid was added to pH 4
  5. filtrationThe white precipitate was filtered off
  6. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-4af3bbe7023a4bd1bc4c638c8bdf57ba
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159329

연결된 노트

불러오는 중…