Formamide → 7-Nitroquinazolin-4(3H)-one

HRID 237315

반응식

HRID 237315 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:14]([NH2:16])=O.C([O-])(O)=O.[Na+]>>[N+:11]([C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:6])[NH:16][CH:14]=[N:1]2)=[CH:7][CH:8]=1)([O-:13])=[O:12]

참가 물질

4

반응물 3

HCID 713FormamideHCID 120764-Nitroanthranilic acidHCID 516892Sodium Bicarbonate

생성물 1

HCID 862228007-Nitroquinazolin-4(3H)-one수율 70.4%

반응 조건

온도
150 °C

실험 절차

A mixture of 2-amino-4-nitrobenzoic acid (5.0 g, 27.5 mmol) and formamide (8.0 ml, 201.5 mmol) in a microwave reaction vessel was heated in a microwave reactor at 150° C. for 1 hr. The slurry was cooled to rt, stirred with aq. NaHCO3, filtered, washed with water followed by ether and dried in vacuum oven to provide 3.7 g of 7-nitroquinazolin-4(3H)-one (Compound 98-1).

후처리

  1. customin a microwave reaction vessel
  2. temperatureThe slurry was cooled to rt
  3. filtrationfiltered
  4. washwashed with water
  5. customdried in vacuum oven

출처 및 근거

ORD 기록
ord-43df6153f9214497a90881c77e95dd32
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642582B2

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