Phenol → 2-Chloro-6-phenoxypyridine

HRID 2415171

반응식

HRID 2415171 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+]>O>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:15][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 996PhenolHCID 14798Sodium Hydroxide2회HCID 169892,6-Dichloropyridine

생성물 1

HCID 8176622-Chloro-6-phenoxypyridine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
140 °C

실험 절차

A reaction mixture consisting of 1.48 g (10 mmol) of 2,6-dichloropyridine, 6 g (63.75 mmol) of phenol and 2.4 g (60 mmol) of sodium hydroxide in 10 ml of water is heated to 140° C. for 24 hours in a bomb. After cooling the reaction mixture is made strongly alkaline with sodium hydroxide solution and extracted with dichloromethane. The organic phase is separated off and dried over sodium sulphate. Purification is by column chromatography on silica gel (eluant: cyclohexane/ethyl acetate=3:1).

후처리

  1. temperatureAfter cooling the reaction mixture
  2. extractionextracted with dichloromethane
  3. customThe organic phase is separated off
  4. dry with materialdried over sodium sulphate
  5. customPurification

출처 및 근거

ORD 기록
ord-ac707bb3264f428cb065a83624731042
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06818644B1

연결된 노트

불러오는 중…