Cyanoacetamide → Milrinone

HRID 2417648

반응식

HRID 2417648 반응식
[CH3:1][C:2]([C:4]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)=[CH:5]OCC)=O.[C:15]([CH2:17][C:18]([NH2:20])=[O:19])#[N:16].[OH-].[Na+]>CO>[CH3:1][C:2]1[NH:20][C:18](=[O:19])[C:17](=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)[C:15]#[N:16]

참가 물질

5

반응물 3

HCID 7898Cyanoacetamide2회HCID 14798Sodium HydroxideHCID 30212274-Ethoxy-3-(4-pyridyl)-3-buten-2-one

생성물 1

HCID 4197Milrinone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The process according to claim 4 where 2-ethoxy-1-(4-pyridinyl)ethenyl methyl ketone is reacted with cyanoacetamide in the presence of at least a molar equivalent quantity of sodium hydroxide per mole of cyanoacetamide in methanol and the reaction mixture is neutralized to produce 1,2-dihydro-6-methyl-2-oxo-5-(4-pyridinyl)nicotinonitrile.

출처 및 근거

ORD 기록
ord-ca57537861834c5ab7e20e5a6689ba3f
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04469871

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