4-Hydroxybenzoic Acid → Benzoic acid, 4-((1-oxodecyl)oxy)-

HRID 247802

반응식

HRID 247802 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:21])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].CN(C1C=CC=CN=1)C.Cl>C(Cl)Cl.O.C(N(CC)CC)C>[CH2:12]([C:11]([O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)=[O:21])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

8

반응물 4

HCID 1354-Hydroxybenzoic AcidHCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 66982Decanoyl chloride

생성물 1

HCID 3608562Benzoic acid, 4-((1-oxodecyl)oxy)-수율 42.5%

시약·촉매·용매 3

HCID 962Water용매HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

A solution of 4-hydroxybenzoic acid (3 g), decanoic acid chloride (4.3 g), triethylamine (2.4 g) and dimethylaminopyridine (0.2 g) in methylene chloride (50 ml) was stirred at room temperature for 24 hours, and then poured in water. The solution was neutralized with dilute aqueous hydrochloric acid solution and extracted with dimethyl ether. The extracted product was dried over anhydrous magnesium sulfate and distilled to remove the solvent. The residue was washed enough with hexane to obtain the titled compound (2.7 g).

후처리

  1. extractionextracted with dimethyl ether
  2. dry with materialThe extracted product was dried over anhydrous magnesium sulfate
  3. distillationdistilled
  4. customto remove the solvent
  5. washThe residue was washed enough with hexane

출처 및 근거

ORD 기록
ord-081baeb5b5c44533a76afd5b27c1e8e0
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05207947

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