4-Methylmorpholine → Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester

HRID 248816

반응식

HRID 248816 반응식
[C:1]([OH:11])(=O)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl.[CH3:13][O:14][C:15](=[O:18])[CH2:16][NH2:17].C1(N=C=NC2CCCCC2)CCCCC1.ON1C2C=CC=CC=2N=N1.CN1CCOCC1>CN(C)C=O>[CH3:13][O:14][C:15](=[O:18])[CH2:16][NH:17][C:1](=[O:11])[CH:2]=[CH:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

7

반응물 5

HCID 79724-MethylmorpholineHCID 87842-Propenoic acid, 3-phenyl-HCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 122755Glycine methyl ester hydrochloride

생성물 1

HCID 582979Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Cinnamic acid (38.0 g) was coupled to glycine methyl ester hydrochloride in dimethylformamide by treatment with dicyclohexylcarbodiimide (52.84 g) and 1-hydroxybenzotriazole (39.24 g), followed by N-methylmorpholine (37.56 ml). The reaction mixture was stirred overnight at room temperature and then worked up in the usual manner to give the desired product.

출처 및 근거

ORD 기록
ord-ecf315e47df3405c9faf417599866d90
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212158

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