Glycine → N-Dodecamidoglycine

HRID 252473

반응식

HRID 252473 반응식
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].C(N(C(C)C)CC)(C)C.[CH2:15]([N:27]=C=O)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].CN(C=[O:34])C>O.O1CCCC1>[C:15]([NH:27][NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[O:34])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

7

반응물 4

HCID 750GlycineHCID 6228DimethylformamideHCID 77873Dodecane, 1-isocyanato-HCID 81531Diisopropylethylamine

생성물 1

HCID 86599604N-Dodecamidoglycine

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

Glycine (0.40 g, 5.25 mmol) and 0.91 mL of diisopropylethylamine (5.25 mmol) were dissolved in 4 mL DMF and 6 mL water. Dodecylisocyanate (0.72 mL, 3.0 mmol) in 7 mL tetrahydrofuran was added and the mixture was stirred for 1 h at room temperature. Water (40 mL) was added and the resulting mixture was washed with ethyl acetate twice. The aqueous layer was acidified with 6N HCl, the resulting precipitate was filtered, and then dried to provide 575 mg of the title compound.

후처리

  1. washthe resulting mixture was washed with ethyl acetate twice
  2. filtrationthe resulting precipitate was filtered
  3. customdried

출처 및 근거

ORD 기록
ord-107a21eddf7c429fa48da28ebabfc9ee
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868135B2

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