Hydrochloric Acid → HCID 14010319, 화합물

HRID 257150

반응식

HRID 257150 반응식
O.[OH:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([O-:10])=[O:9])=[CH:5][CH:4]=1.[Na+].[OH-].[Na+].[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Cl>O>[CH2:17]([O:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7503Benzyl ChlorideHCID 14798Sodium Hydroxide2회HCID 236981332-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate

생성물 1

HCID 14010319HCID 14010319, 화합물수율 69%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 41.6 g (0.20 mol) of sodium 4-hydroxymandelate monohydrate, 9.6 g (0.24 mol) of sodium hydroxide and 27.9 g (0.22 mol) of benzyl chloride in 50 ml of water is stirred for 17 hours at 70° C. It is then diluted using 50 ml of water, and a further 4.0 g (0.10 mol) of sodium hydroxide are added. The reaction mixture is refluxed for one hour, then cooled and acidified using concentrated hydrochloric acid, and the product which has precipitated is filtered. The residue is washed with cold water and subsequently dried under a high vacuum. 35.6 g (69%) of 4-benzyloxymandelic acid, m.p. 148°-155° C., result.

후처리

  1. additionIt is then diluted
  2. temperatureThe reaction mixture is refluxed for one hour
  3. temperaturecooled
  4. customthe product which has precipitated
  5. filtrationis filtered
  6. washThe residue is washed with cold water
  7. customsubsequently dried under a high vacuum

출처 및 근거

ORD 기록
ord-15c46ef995b14f4b98d4d42579242328
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05260430

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