Hydrochloric Acid → 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid
반응식
[F:1][C:2]([F:15])([F:14])[C:3]([NH:5][C@@H:6]1[C:12](=[O:13])[O:11][C:9](=[O:10])[CH2:8][CH2:7]1)=[O:4].[Al+3].[Cl-].[Cl-].[Cl-].Cl.C(O[CH2:25][CH3:26])(=O)C>C1C=CC=CC=1>[C:9]([CH2:8][CH2:7][C@H:6]([NH:5][C:3](=[O:4])[C:2]([F:15])([F:14])[F:1])[C:12]([OH:11])=[O:13])(=[O:10])[C:26]1[CH:25]=[CH:8][CH:7]=[CH:6][CH:12]=1참가 물질
6
실험 절차
Heat at reflux for 3 hours a mixture of N-trifluoroacetyl-L-glutamic anhydride (18.0 g, 80 mmol) and AlCl3 (23.5 g, 177 mmol) in dry benzene (400 ml). Allow to cool, treat with ice (400 ml), conc. HCl (100 ml), and ethyl acetate (EtOAc) (400 ml). Dry the organic layer and concentrate to obtain the title compound as a brown crystalline solid (25 g).
후처리
- temperatureHeat
- temperatureat reflux for 3 hours
- temperatureAllow to cool
- customDry the organic layer
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-46bd8a2309e340c792f0e0c9cc52a5c5
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05262436
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