Ammonia → 2-Amino-5-fluorobenzoic acid

HRID 259920

반응식

HRID 259920 반응식
[Na].[F:2][C:3]1[CH:4]=[CH:5][C:6](Br)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9].[K].[NH3:14]>[OH-].[K+]>[F:2][C:3]1[CH:11]=[C:7]([C:8]([OH:10])=[O:9])[C:6]([NH2:14])=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 27781812-Bromo-5-fluorobenzoic acid2회HCID 5360545SodiumHCID 5462222Potassium

생성물 1

HCID 1014122-Amino-5-fluorobenzoic acid

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

실험 절차

If the sodium salt solution of 5-fluoro-2-bromobenzoic acid is replaced by aliquot parts of the potassium or ammonium salt solution, prepared by dissolving 219 parts of 5-fluoro-2-bromobenzoic acid in 256.1 parts of 21.9% strength aqueous potassium hydroxide or, respectively, 217 parts of 7.9% aqueous ammonia solution and used as the metering medium in a procedure otherwise identical to that indicated, then 5-fluoroanthranilic acid is obtained in identical yield and quality.

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-4f2f20decea5457bb0487fd375f40d1a
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523472

연결된 노트

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