Hydrogen Bromide → 2-Bromo-1-(1-naphthalenyl)ethanone
반응식
[C:1]1([C:11]([CH3:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(Cl)(Cl)Cl.[BrH:18]>[Cu](Br)Br.C(OCC)(=O)C>[C:1]1([C:11]([CH2:13][Br:18])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1참가 물질
6
실험 절차
Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.
후처리
- additionis treated with 26.5 g
- customThe resulting reaction mixture
- temperatureis heated
- temperatureunder reflux
- customis removed
- additionether is added
- customthe copper (I) bromide is removed by filtration
- customEvaporation of the filtrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-1489e7152d2f4faab50106df544efc62
- 출처 데이터셋
- uspto-grants-1979_04
- 특허 번호
- US04150153
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