Hydrogen Bromide → 2-Bromo-1-(1-naphthalenyl)ethanone

HRID 26539

반응식

HRID 26539 반응식
[C:1]1([C:11]([CH3:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(Cl)(Cl)Cl.[BrH:18]>[Cu](Br)Br.C(OCC)(=O)C>[C:1]1([C:11]([CH2:13][Br:18])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 260Hydrogen BromideHCID 6212ChloroformHCID 136631-Acetylnaphthalene

생성물 1

HCID 38305132-Bromo-1-(1-naphthalenyl)ethanone

시약·촉매·용매 2

HCID 24611Copper bromide (CuBr2)촉매HCID 8857Ethyl Acetate용매

실험 절차

Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.

후처리

  1. additionis treated with 26.5 g
  2. customThe resulting reaction mixture
  3. temperatureis heated
  4. temperatureunder reflux
  5. customis removed
  6. additionether is added
  7. customthe copper (I) bromide is removed by filtration
  8. customEvaporation of the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-1489e7152d2f4faab50106df544efc62
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150153

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