Aminoacetaldehyde → 1-(alpha-Phenyl-o-tolyl)imidazole

HRID 267416

반응식

HRID 267416 반응식
[C:1]1([CH2:7][C:8]2[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:15](OC)(OC)OC.[NH2:22][CH2:23][CH:24]=O>C(COC)OC.[Ti](Cl)(Cl)(Cl)Cl>[C:1]1([CH2:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]2[CH:24]=[CH:23][N:22]=[CH:15]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 363AminoacetaldehydeHCID 9005Trimethyl orthoformateHCID 1198052-Benzylaniline

생성물 1

HCID 214973581-(alpha-Phenyl-o-tolyl)imidazole

시약·촉매·용매 2

HCID 24193Titanium Tetrachloride촉매HCID 80711,2-Dimethoxyethane용매

실험 절차

In the manner given in Preparation 21, α-phenyl-o-toluidine is reacted first with trimethyl orthoformate, the resulting product is reacted with aminoacetaldehyde, dimethyl acetal, and the resulting product of this reaction is heated with titanium tetrachloride in monoglyme to give 1-(α-phenyl-o-tolyl)imidazole.

출처 및 근거

ORD 기록
ord-95c6e07595134a3592a956073228a28d
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941803

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