Dimethylamine, hydrochloride → Dimethyl-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-amine
반응식
[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([CH:10]=O)[CH:9]=[C:4]2[CH:3]=[CH:2]1.Cl.[CH3:13][NH:14][CH3:15].[OH-].[Na+].C([BH3-])#N.[Na+]>CO.O>[CH3:13][N:14]([CH3:15])[CH2:10][C:8]1[CH:9]=[C:4]2[CH:3]=[CH:2][NH:1][C:5]2=[N:6][CH:7]=1참가 물질
7
실험 절차
To 1H-Pyrrolo[2,3-b]pyridine-5-carbaldehyde (114 mg, 0.78 mmol), in methanol (10 ml) was added dimethylamine hydrochloride (127 mg, 1.56 mmol, NaOH (31.2 mg, 0.78 mmol), sodium cyanoborohydride (49 mg, 0.78 mmol) and the solution was stirred under nitrogen for 12 hr. Poured into water (50 mL), extracted with ethyl acetate, dried (Na2SO4) to afforded Dimethyl-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-amine (44 mg, 33% yield) used without purification. MS: m/e 176.1 (M+H).
후처리
- extractionextracted with ethyl acetate
- dry with materialdried (Na2SO4)
출처 및 근거
- ORD 기록
- ord-40b9bc0a873a44b18533dfd18f6659b6
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07446199B2
반응 노트
불러오는 중…