Hydrochloric Acid → HCID 23342859, 화합물

HRID 27407노트

반응식

HRID 27407 반응식
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[OH-:13].[Na+].Cl.C(Cl)(Cl)Cl>O.C(O)C>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([OH:13])=[O:1]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 23342878HCID 23342878, 화합물

생성물 1

HCID 23342859HCID 23342859, 화합물수율 30.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

67.6 g (0.4 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone and 32 g (0.8 mol) of sodium hydroxide in 210 ml of water are heated for 2 hours under reflux, cooled and then acidified with hydrochloric acid to a pH value of 1. The reaction mixture is evaporated to dryness under reduced pressure and the residue taken up three times in benzene and evaporated in vacuo. The residue obtained is finally treated with a mixture of chloroform and ethanol (4:1 v/v) and the insoluble material filtered off. The filtrate is evaporated and the residue is recrystallized from ethanol. 22.7 g (yield: 30% of theory) of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetic acid are obtained. M.P.: 123°-124° C.

후처리

  1. temperatureunder reflux
  2. temperaturecooled
  3. customThe reaction mixture is evaporated to dryness under reduced pressure
  4. customevaporated in vacuo
  5. customThe residue obtained
  6. filtrationthe insoluble material filtered off
  7. customThe filtrate is evaporated
  8. customthe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-99b428fde9a147f19afbe43967e2b0bf
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221789

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