Sodium hydride → HCID 15239119, 화합물

HRID 274357

반응식

HRID 274357 반응식
[SH:1][C:2]1[S:3][CH2:4][CH2:5][N:6]=1.[H-].[Na+].[Na].[CH3:10][CH:11](Br)[CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[CH:16][CH:15]=1>>[CH3:10][CH:11]([S:1][C:2]1[S:3][CH2:4][CH2:5][N:6]=1)[CH2:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([S:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[CH:18][CH:19]=1

참가 물질

5

반응물 4

HCID 24758Sodium hydrideHCID 5360545SodiumHCID 15239125HCID 15239125, 화합물HCID 178527880HCID 178527880, 화합물

생성물 1

HCID 15239119HCID 15239119, 화합물

실험 절차

Generally following the procedure of Example 7, 2-mercapto-2-thiazoline (0.67 g, 5.6 mmol) is treated with sodium hydride (0.35 g, 7.3 mmol), with cooling, and the resulting sodium salt is reacted with 1-methyl-2-[4-(1methylpropylthio)phenoxy]ethyl bromide (1.70 g, 5.6 mmol) at RT to give 2-{1-methyl-2-[4-(1-methylpropylthio)phenoxy]ethylthio}-2-thiazoline.

후처리

  1. temperaturewith cooling

출처 및 근거

ORD 기록
ord-e8df4daf53eb4aa58097930efe075e3b
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389651

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