Hydrochloric Acid → 6-Methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([CH3:13])=[N:8][CH2:7][CH2:6]2.[BH4-].[Na+].Cl.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([CH3:13])[NH:8][CH2:7][CH2:6]2참가 물질
6
실험 절차
6-methoxy-1-methyl-3,4-dihydroisoquinoline (54.0 g, 0.31 mmol) was added to a suspension of sodium borohydride(5.8 g, 138 mmol) in ethanol. The mixture solution was stirred for 1 hour at a room temperature, cooled to below 5° C., acidified with diluted hydrochloric acid, adjusted to alkali with sodium hydroxide solution, and then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure to give 45.4 g of the titled compound.
후처리
- temperaturecooled to below 5° C.
- extractionextracted with ethyl acetate
- dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
- concentrationconcentrated under a reduced pressure
출처 및 근거
- ORD 기록
- ord-0d7c703eacdf49228d4185d8be026748
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06352993B1
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