Glyoxylic Acid → (+-)-4-Hydroxymandelic acid

HRID 278530

반응식

HRID 278530 반응식
[C:1]([OH:5])(=[O:4])[CH:2]=[O:3].[C:6]1([OH:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O>[OH:12][C:6]1[CH:11]=[CH:10][C:9]([CH:2]([OH:3])[C:1]([OH:5])=[O:4])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 760Glyoxylic AcidHCID 996Phenol

생성물 1

HCID 328(+-)-4-Hydroxymandelic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The European patent specification EP-0,368,696 describes the condensation of a glyoxylic acid with phenol in the presence of a water-insoluble amine, to form a 12:84 mixture of 2- and 4-hydroxymandelic acid respectively. Then the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane. Only 70-74% of the paraisomer, 4-hydroxymandelic acid, is isolated leaving a non-separable mixture of approximately 1:1 2- and 4-hydroxymandelic acid.

후처리

  1. customto form
  2. extractionThen the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane

출처 및 근거

ORD 기록
ord-89b113ed39194d25bd2436f24bca2c8a
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359172B1

연결된 노트

불러오는 중…