Glyoxylic Acid → (+-)-4-Hydroxymandelic acid
반응식
[C:1]([OH:5])(=[O:4])[CH:2]=[O:3].[C:6]1([OH:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O>[OH:12][C:6]1[CH:11]=[CH:10][C:9]([CH:2]([OH:3])[C:1]([OH:5])=[O:4])=[CH:8][CH:7]=1참가 물질
4
실험 절차
The European patent specification EP-0,368,696 describes the condensation of a glyoxylic acid with phenol in the presence of a water-insoluble amine, to form a 12:84 mixture of 2- and 4-hydroxymandelic acid respectively. Then the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane. Only 70-74% of the paraisomer, 4-hydroxymandelic acid, is isolated leaving a non-separable mixture of approximately 1:1 2- and 4-hydroxymandelic acid.
후처리
- customto form
- extractionThen the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane
출처 및 근거
- ORD 기록
- ord-89b113ed39194d25bd2436f24bca2c8a
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06359172B1
반응 노트
불러오는 중…