Hydrochloric Acid → 5-Acetyl-1,3-benzoxazol-2(3H)-one

HRID 28392

반응식

HRID 28392 반응식
C(N(CC)CC)C.ClC(Cl)(O[C:12](=[O:18])[O:13][C:14](Cl)(Cl)Cl)Cl.[NH2:20][C:21]1[CH:26]=[C:25]([C:27]([CH3:29])=[O:28])[CH:24]=[CH:23]C=1O.Cl>C1COCC1>[CH3:29][C:27]([C:25]1[CH:24]=[CH:23][C:14]2[O:13][C:12](=[O:18])[NH:20][C:21]=2[CH:26]=1)=[O:28]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 94429TriphosgeneHCID 137241423'-Amino-4'-hydroxyacetophenone

생성물 1

HCID 151135715-Acetyl-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

7.8 ml of triethylamine and 2.75 g (0.0093 mol) of triphosgene are added to a mixture of 4.2 g (0.0277 mol) of 2-amino-4-methylcarbonylphenol in 100 ml of THF, at 0° C. The mixture is stirred at room temperature for 1 hour, poured into 100 ml of a 0.5N HCl solution and extracted with ethyl acetate, the organic phase is dried and the solvent is evaporated off. The compound of the title is obtained.

후처리

  1. extractionextracted with ethyl acetate
  2. customthe organic phase is dried
  3. customthe solvent is evaporated off
  4. customThe compound of the title is obtained

출처 및 근거

ORD 기록
ord-24754a8a8d0d46a5b2104443d26209ef
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419974B2

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