Sodium Chloride → N-[1-(4-aminophenyl)ethylidene]hydroxylamine

HRID 28616

반응식

HRID 28616 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][CH:3]=1.Cl.[NH2:12][OH:13].[OH-].[Na+].[Cl-].[Na+]>C(O)C.O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:12][OH:13])[CH3:9])=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 5234Sodium ChlorideHCID 7468p-AminoacetophenoneHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 254131N-[1-(4-aminophenyl)ethylidene]hydroxylamine수율 30%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a mixture of 1-(4-amino-phenyl)-ethanone (2.75 g, 20.3 mmol) and hydroxylamine hydrochloride salt (2.1 g, 30.5 mmol) in ethanol (200 ml) was added sodium hydroxide (4.1 g, 101.7 mmol) in water (50 ml). After stirring for 18 hours, the mixture was treated with saturated aqueous sodium chloride solution (100 ml) and extracted with dichloromethane (200 ml). The organic extract was concentrated under reduced pressure to afford 1-(4-amino-phenyl)-ethanone-oxime (30% yield).

후처리

  1. extractionextracted with dichloromethane (200 ml)
  2. extractionThe organic extract
  3. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4d7aca234a664cbe99991eb96404e5e8
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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