Sodium hydride → Trimethylsilylethoxymethyltetrazole

HRID 2977

반응식

HRID 2977 반응식
[H-].[Na+].[NH:3]1[CH:7]=[N:6][N:5]=[N:4]1.[CH3:8][Si:9]([CH2:12][CH2:13][O:14][CH2:15]Cl)([CH3:11])[CH3:10]>CN(C=O)C>[CH3:8][Si:9]([CH2:12][CH2:13][O:14][CH2:15][C:7]1[NH:6][N:5]=[N:4][N:3]=1)([CH3:11])[CH3:10]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 178418441HCID 178418441, 화합물

생성물 1

HCID 178418485Trimethylsilylethoxymethyltetrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

To a Suspension of 1.1 mmol NaH in 5 mL DMF at 0° C. was added a solution of 1.0 mmol tetrazole in 2 mL DMF. After 30 min, trimethylsilylethoxymethylchloride was added and the mixture stirred for 16 h. Extraction and chromatography provided trimethylsilylethoxymethyltetrazole as an oil.

후처리

  1. extractionExtraction and chromatography

출처 및 근거

ORD 기록
ord-dfbffeb92a874b419566deb178159f88
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731432

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