4-Methoxybenzenesulfonyl chloride → L-Aspartic Acid
반응식
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].COC1C=CC(S(Cl)(=O)=O)=CC=1>[OH-].[Na+]>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5]참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
D-Aspartic acid (2.66 g) is suspended in 2N NaOH (30 mL) and 4-methoxyphenylsulfonyl chloride (4.12 g) is added. The mixture is stirred at 70° C. for 5 hours (clear solution), cooled down to room temperature and extracted with methylene chloride. The aqueous phase, after acidifying with 12N HCl, is extracted with ethyl acetate. The combined organic phases are with brine, dried (Na2SO4) and concentrated under reduced pressure to give N-[4-methoxyphenyl)sulfonyl]-D-aspartic acid as a white solid.
후처리
- temperaturecooled down to room temperature
- extractionextracted with methylene chloride
- extractionis extracted with ethyl acetate
- dry with materialdried (Na2SO4)
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-de226369a28f4cc8b18b16c2cda762da
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06218389B1
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