Hydrochloric Acid → HCID 11068249, 화합물

HRID 324622노트

반응식

HRID 324622 반응식
[CH2:1]([C:4]1[C:5]([OH:21])=[C:6]([Br:20])[CH:7]=[C:8]2[C:12]=1[C@H:11]([CH2:13][CH2:14][NH:15][C:16](=[O:19])[CH2:17][CH3:18])[CH2:10][CH2:9]2)[CH:2]=C.[O:22]=[O+][O-].[BH4-].[Na+].Cl>CO>[Br:20][C:6]1[CH:7]=[C:8]2[C:12](=[C:4]([CH2:1][CH2:2][OH:22])[C:5]=1[OH:21])[C@H:11]([CH2:13][CH2:14][NH:15][C:16](=[O:19])[CH2:17][CH3:18])[CH2:10][CH2:9]2

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 24823OzoneHCID 4311764Sodium borohydrideHCID 10861106(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-YL]ethyl]propanamide

생성물 1

HCID 11068249HCID 11068249, 화합물수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of (S)-N-[2-(7-allyl-5-bromo-6-hydroxyindan-1-yl)ethyl]propionamide (588 mg, 1.67 mmol.) in methanol (30 mL) was cooled to about −70° C., to which was introduced ozone for 5 minutes. After confirming the disappearance of the starting material, an excess amount of powdery sodium borohydride (510 mg, 13.4 mmol.) was added to reaction mixture at about −70° C. to decompose ozonide. The reaction mixture was warmed to room temperature, which was neutralized with dilute hydrochloric acid, followed by extracting the organic matter with a mixture of ethyl acetate:butanol=1:1. The extract solution was dried over anhydrous magnesium sulfate, from which the solvent was distilled off under reduced pressure. The residue was then washed with diethyl ether to afford the title compound (yield 0.59 g, 99%).

후처리

  1. extractionby extracting the organic matter
  2. additionwith a mixture of ethyl acetate
  3. dry with materialThe extract solution was dried over anhydrous magnesium sulfate, from which the solvent
  4. distillationwas distilled off under reduced pressure
  5. washThe residue was then washed with diethyl ether

출처 및 근거

ORD 기록
ord-75346678b8e54726aa47cecd5e175864
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218429B1

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