Hydrochloric Acid → AL 321

HRID 326159노트

반응식

HRID 326159 반응식
CS(O[CH:6]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]([CH3:29])([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH3:22])=[CH:15][CH:14]=1)[C:7]([O:9]CC)=O)(=O)=O.[NH2:30][C:31](N)=[S:32].S1(CCCC1)(=O)=[O:35].Cl>O>[CH3:29][C:21]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)([CH3:22])[CH2:20][O:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][CH:6]2[S:32][C:31](=[O:35])[NH:30][C:7]2=[O:9])=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 20462533HCID 20462533, 화합물

생성물 1

HCID 194620AL 321

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

2.1 g Of ethyl 2-methanesulfonyloxy-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate and 0.76 g of thiourea are added to 20 ml of sulfolane, and the mixture is heated at 120° C. with stirring for one hour. After adding 10 ml of 2 N-hydrochloric acid, the mixture is heated at 100° C. for 8 hours. After cooling, water is added to the mixture, and the mixture is subjected to extraction with ether. The extract is washed with water and dried. The ether is distilled off to give 1.3 g of 5-[4-(2-methyl-2-phenylpropyloxy)benzyl]thiazolidine-2,4-dione.

후처리

  1. temperaturethe mixture is heated at 100° C. for 8 hours
  2. temperatureAfter cooling
  3. extractionthe mixture is subjected to extraction with ether
  4. washThe extract is washed with water
  5. customdried
  6. distillationThe ether is distilled off

출처 및 근거

ORD 기록
ord-87a232cffb3d442fb954b3640d450f9e
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04444779

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