Benzyl Chloride → Benzyl 4-methyl-2-oxopentanoate

HRID 326377

반응식

HRID 326377 반응식
[Na+].[O:2]=[C:3]([CH2:7][CH:8]([CH3:10])[CH3:9])[C:4]([O-:6])=[O:5].[CH2:11](Cl)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CN(C=O)C.C(Cl)(Cl)Cl>[CH3:9][CH:8]([CH3:10])[CH2:7][C:3](=[O:2])[C:4]([O:6][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5]

참가 물질

5

반응물 2

HCID 7503Benzyl ChlorideHCID 4137900Sodium 4-methyl-2-oxovalerate

생성물 1

HCID 4072499Benzyl 4-methyl-2-oxopentanoate수율 94%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2-Oxo-4-methyl pentanoic acid sodium salt (10 g, 65.7 mmol) and benzyl chloride (8 g, 63 mmol) in 300 ml DMF was stirred at 40°-50° C. for 5 h. It was filtered, and the filtrate was evaporated under reduced pressure to provide an oil. The oil was dissolved in chloroform, washed with water, dried, filtered, and evaporated to provide the desired product (13 g, 94%). 1H NMR (CDCl3, TMS) δ0.95 (d,6H), 2.15 (m,1H), 2.7 (d,2H), 5.28 (s,2H), 7.4 (m,5H). Mass spectrum: (M+H)+ =221.

후처리

  1. filtrationIt was filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. customto provide an oil
  4. washwashed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-17556ae88132457880ffb3476e669674
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05268374

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