Hydrochloric Acid → 3,4,5-Trimethoxyphenylacetic acid

HRID 327499

반응식

HRID 327499 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]#N)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[OH-:16].[Na+].Cl.C[OH:20].O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]([OH:20])=[O:16])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 258873,4,5-Trimethoxyphenylacetonitrile2회HCID 22242641Methanol--water (1/1)

생성물 1

HCID 703723,4,5-Trimethoxyphenylacetic acid

실험 절차

3,4,5-trimethoxyphenyl acetonitrile 5.5 g was dissolved into 50 ml of methanol/water (9:1). To this 1 .5 g of sodium hydroxide was added and they were then stirred and refluxed for 5.5 hours. The temperature of the reactive liquid was lowered down to room temperature and neutralized with 2N hydrochloric acid, and the methanol was distilled off under reduced pressure. Extraction was performed thrice by means of 100 ml of chloroform. After distilling off the solvent under reduced pressure, 5.8 g of captioned compound was obtained.

후처리

  1. temperaturerefluxed for 5.5 hours
  2. distillationthe methanol was distilled off under reduced pressure
  3. extractionExtraction
  4. distillationAfter distilling off the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-e7187962b89b4a35b63770f24bc46a23
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273985

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