Hydrochloric Acid → 2-Acetamido-2,3-dimethylbutanoic acid
반응식
[NH2:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[C:3]([OH:5])=[O:4].[C:10](OC(=O)C)(=[O:12])[CH3:11].Cl>[OH-].[Na+]>[C:10]([NH:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[C:3]([OH:5])=[O:4])(=[O:12])[CH3:11]참가 물질
5
실험 절차
To a stirred solution of 2-amino-2,3-dimethylbutyric acid (13.1 g) in 55 ml 2N NaOH maintained at 5° C is added simultaneously dropwise but separately 17 ml acetic anhydride and 95 ml 2N NaOH so that the pH of the solution is maintained at about 8.5. After stirring at room temperature for a further 1/2 hour, the mixture is acidified with concentrated HCl and the product, (±)-2-acetylamino-2,3-dimethylbutyric acid, removed by filtration, washed with cold water and air-dried. A sample recrystallized from acetonitrile had melting point 189°-190° C.
후처리
- additionis added simultaneously dropwise
- customthe product, (±)-2-acetylamino-2,3-dimethylbutyric acid, removed by filtration
- washwashed with cold water
- customair-dried
- customA sample recrystallized from acetonitrile
출처 및 근거
- ORD 기록
- ord-b414557362894aa4bce70175f46af473
- 출처 데이터셋
- uspto-grants-1977_04
- 특허 번호
- US04017510
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