Cyanuric chloride → 2-Chloro-4,6-bis[(oxiran-2-yl)methoxy]-1,3,5-triazine

HRID 330348노트

반응식

HRID 330348 반응식
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[O:10]1[CH2:14][CH:11]1[CH2:12][OH:13].[OH-:15].[Na+]>C(Cl)(Cl)Cl>[Cl:3][C:2]1[N:4]=[C:5]([O:13][CH2:12][CH:11]2[O:10][CH2:14]2)[N:7]=[C:8]([O:15][CH2:12][CH:11]2[O:10][CH2:14]2)[N:1]=1

참가 물질

5

반응물 3

HCID 7954Cyanuric chlorideHCID 11164GlycidolHCID 14798Sodium Hydroxide

생성물 1

HCID 187799312-Chloro-4,6-bis[(oxiran-2-yl)methoxy]-1,3,5-triazine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a mechanically stirred solution of 220.8 g (1.2 mol) cyanuric chloride in 1500 ml chloroform, cooled to 0°-10° C., was added 266.4 g (3.6 mol) 2,3-epoxy-1-propanol in one portion. Aqueous sodium hydroxide (50% solution; 192 g) was added to the mixture dropwise with stirring over about 3 hr maintaining the reaction temperature below 10° C. and preferably around 0°-5° C. The reaction mixture was allowed to warm slowly to room temperature. The chloroform layer was washed with distilled water until neutral and dried over magnesium sulfate. The reaction product was found by nuclear magnetic resonance to be 2-chloro-4,6-diglycidoxy-1,3,5-triazine. Analysis showed about 95% (by weight) chlorodiglycidoxytriazine. The reaction mixture also was found to contain small amounts of triglycidoxytriazine and dichloro monoglycidoxytriazine.

후처리

  1. temperaturemaintaining the reaction temperature below 10° C. and preferably around 0°-5° C
  2. washThe chloroform layer was washed with distilled water until neutral and
  3. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-082ba3701cbf478cab5efa205c7b6b08
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04895945

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