Azobisisobutyronitrile → 2-Bromoindenone

HRID 331255

반응식

HRID 331255 반응식
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[Br:11]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Br:11][C:2]1[C:1](=[O:10])[C:9]2[C:4]([CH:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 118153841H-inden-1-one

생성물 1

HCID 99906492-Bromoindenone

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

The indenone compound of formula 16 prepared in Step 3 is dissolved in CCl4, N-bromosuccinimide (1 to 1.2 eq) and 2,2′-azobisisobutyronitrile (10 to 15 wt %) are added thereto. The resulting mixture is allowed to reflux for 2 to 3 h with stirring, to obtain the 2-bromoindenone of formula 17.

후처리

  1. temperatureto reflux for 2 to 3 h

출처 및 근거

ORD 기록
ord-fd65a78cb4b1405d8b8fc847e893edc2
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877747B2

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