Hydrochloric Acid → Benzaldehyde, 2-fluoro-, oxime

HRID 332292노트

반응식

HRID 332292 반응식
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:11][OH:12].[OH-].[Na+].Cl>C(O)C.O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[N:11][OH:12]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67970o-FluorobenzaldehydeHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 587025Benzaldehyde, 2-fluoro-, oxime수율 97%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a suspension of 2-fluorobenzaldehyde (63.3 g, 495 mmol) and hydroxylamine hydrochloride (38.2 g, 544 mmol) in ethanol (36 mL) and water (69 mL) was added ice (205 g). Then an aqueous solution of sodium hydroxide (32%, 115 mL, 1.24 mol) was added dropwise within a 10 min period (temperature rises from −8° C. to +7° C.) whereupon most of the solid dissolves. After 1 h stirring at room temperature the resulting mixture was then acidified with HCl (5 N). The mixture was then extracted with dichloromethane to afford the title compound (66.8 g, 97%) which was obtained as a light yellow solid. MS m/e (EI): 139.0 [M].

후처리

  1. dissolutiondissolves
  2. extractionThe mixture was then extracted with dichloromethane

출처 및 근거

ORD 기록
ord-8b54bae6d4754ae184597c05959a7135
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877783B2

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