Hydrochloric Acid → 1H-thieno[2,3-c]pyrazole-5-carbonitrile

HRID 34075

반응식

HRID 34075 반응식
C([N:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1)(=O)C.Cl>C(O)C.[OH-].[Na+]>[NH:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 689272371-Acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile

생성물 1

HCID 689269941H-thieno[2,3-c]pyrazole-5-carbonitrile수율 100.2%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.

후처리

  1. additionwas added at room temperature
  2. extractionextracted with ethyl acetate
  3. washthe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-fe2c8efc4b0447988675b250e4cc7df3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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