Hydrochloric Acid → 5-Chloro-1H-pyrazolo(4,3-d)pyrimidine
반응식
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[N:10](C(=O)C)[N:9]=[CH:8][C:6]=2[N:7]=1.[OH-].[Na+].Cl>C(#N)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[NH:10][N:9]=[CH:8][C:6]=2[N:7]=1참가 물질
5
실험 절차
27 mg of 1-(5-chloro-pyrazolo[4,3-d]pyrimidin-1-yl)-ethanone was dissolved in 1.5 mL of acetonitrile, added with 1.5 mL of 5N sodium hydroxide aqueous solution, and stirred for 2 hours. After adding 2N hydrochloric acid to the reaction solution to render it acidic, the solution was extracted with ethyl acetate, and the resultant organic layer was washed with saturated brine, then dried over magnesium sulfate, and the solvent was evaporated, to afford 16 mg of the title compound.
후처리
- extractionthe solution was extracted with ethyl acetate
- washthe resultant organic layer was washed with saturated brine
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-051dbe47e6fb49a4b437189075b6daeb
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07429609B2
반응 노트
불러오는 중…