Glycine → N-[(allyloxy)carbonyl]glycine

HRID 34279

반응식

HRID 34279 반응식
[CH2:1]([O:4][C:5](Cl)=[O:6])[CH:2]=[CH2:3].[NH2:8][CH2:9][C:10]([OH:12])=[O:11]>O.[OH-].[Na+]>[CH2:1]([O:4][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:6])[CH:2]=[CH2:3]

참가 물질

5

반응물 2

HCID 750GlycineHCID 18052Allyl chloroformate

생성물 1

HCID 11964402N-[(allyloxy)carbonyl]glycine

시약·촉매·용매 2

HCID 962Water용매HCID 14798Sodium Hydroxide용매

실험 절차

At 0°, 12 ml of chloroformic acid allyl ester are added dropwise to a solution of 7.51 g of glycine in 20 ml of water and 44 ml of 5N NaOH solution. The suspension is then stirred for 16 hours at room temperature. After removing the insoluble material by filtration, the filtrate is diluted with 100 ml of water and washed twice with CH2Cl2. The aqueous phase is adjusted to pH 2 with 4N HCl and extracted twice with CH2Cl2. The combined organic extracts are washed once with brine, dried over MgSO4 and concentrated by evaporation to form the white crystals of the title compound.

후처리

  1. customAfter removing the insoluble material
  2. filtrationby filtration
  3. additionthe filtrate is diluted with 100 ml of water
  4. washwashed twice with CH2Cl2
  5. extractionextracted twice with CH2Cl2
  6. washThe combined organic extracts are washed once with brine
  7. dry with materialdried over MgSO4
  8. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-9a103a7e86b8409ea9662cee16a2dda8
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761408

연결된 노트

불러오는 중…