Benzyl Chloride → Methyl 2-(4-benzyloxyphenyl)acetate

HRID 34404

반응식

HRID 34404 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+].[OH-].[Na+]>C(O)C>[CH2:13]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

6

반응물 4

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

생성물 1

HCID 2756645Methyl 2-(4-benzyloxyphenyl)acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl 4-hydroxyphenylacetate (5, 0.2 mol), obtainable from Aldrich Chemical Co. Inc., Milwaukee, Wis., is heated at reflux with benzyl chloride (25 g, 0.2 mol) and K2CO3 (25 g, 0.2 mol) in 100 mL ethanol. The product is added to dilute aqueous NaOH, extracted with ether, and purified by silica gel chromatography to yield methyl 4-benzyloxyphenylacetate (6). (Scheme II, Step 1.)

후처리

  1. temperature, is heated
  2. extractionextracted with ether
  3. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-9c76812738bd47cb8d4850477591476a
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761420

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