Water → 1-Pyrrolidino-1-cyclohexene

HRID 345308

반응식

HRID 345308 반응식
[C:1]1(=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.O>C1C=CC=CC=1>[N:8]1([C:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=2)[CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

5

반응물 3

HCID 962WaterHCID 7967CyclohexanoneHCID 31268Pyrrolidine

생성물 1

HCID 707681-Pyrrolidino-1-cyclohexene수율 95.9%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Cyclohexanone (196.3 g) and pyrrolidine (214 g) in benzene (500 ml) were refluxed under nitrogen with a Dean-Stark apparatus, until no more water separated out. The solvents were then evaporated off under nitrogen, and the residual oil was distilled to give 1-(1-pyrrolidinyl)cyclohexene (290 g).

후처리

  1. customseparated out
  2. customThe solvents were then evaporated off under nitrogen
  3. distillationthe residual oil was distilled

출처 및 근거

ORD 기록
ord-cf667839892a418383ce21ec62dc57f8
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05057513

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