Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid

HRID 34578

반응식

HRID 34578 반응식
[Cl:1][C:2]1[C:10]([N+:11]([O-])=O)=[C:9]([CH3:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O-]S(S([O-])=O)=O.[Na+].[Na+].Cl>COCCO.O>[NH2:11][C:10]1[C:2]([Cl:1])=[C:3]([CH:7]=[C:8]([F:15])[C:9]=1[CH3:14])[C:4]([OH:6])=[O:5]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 24489Sodium DithioniteHCID 136574392-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

생성물 1

HCID 136574403-Amino-2-chloro-5-fluoro-4-methylbenzoic acid

시약·촉매·용매 2

HCID 962Water용매2회HCID 80192-Methoxyethanol용매

실험 절차

18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.

후처리

  1. temperaturecooled
  2. customThe solid which has precipitated
  3. customis isolated
  4. customdried

출처 및 근거

ORD 기록
ord-59d9ecf81f1c4d51bdbef875b42cf00b
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762844

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