Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid
반응식
[Cl:1][C:2]1[C:10]([N+:11]([O-])=O)=[C:9]([CH3:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O-]S(S([O-])=O)=O.[Na+].[Na+].Cl>COCCO.O>[NH2:11][C:10]1[C:2]([Cl:1])=[C:3]([CH:7]=[C:8]([F:15])[C:9]=1[CH3:14])[C:4]([OH:6])=[O:5]참가 물질
6
실험 절차
18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.
후처리
- temperaturecooled
- customThe solid which has precipitated
- customis isolated
- customdried
출처 및 근거
- ORD 기록
- ord-59d9ecf81f1c4d51bdbef875b42cf00b
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04762844
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