Hydrochloric Acid → 4-Carboxy-2-carboxyethylthio-1,3-thiazole
반응식
Br[CH:2]([CH3:6])[C:3]([OH:5])=[O:4].[OH-].[Na+].C([O:11][C:12]([C:14]1[N:15]=[C:16]([SH:19])[S:17][CH:18]=1)=[O:13])C.Cl>O>[C:3]([C:2]1[N:15]=[C:16]([S:17][CH2:18][CH2:14][C:12]([OH:13])=[O:11])[S:19][CH:6]=1)([OH:5])=[O:4]참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
6.9 g of bromopropionic acid were dissolved in 100 ml of water, and the pH was adjusted to 7 with 1N NaOH. This solution was added dropwise to a suspension of 7.5 g of 4-ethoxycarbonyl-2-mercapto-1,3-thiazole in 75 ml of H2O. The pH was adjusted to 8-10 with 2N NaOH, and the mixture was stirred at room temperature for 4 h and at 60° C. for 2 h. The pH was maintained between 8 and 10. While cooling in ice, the mixture was acidified to pH 1 with 2N HCl, and the product was filtered off.
후처리
- temperatureThe pH was maintained between 8 and 10
- temperatureWhile cooling in ice
- filtrationthe product was filtered off
출처 및 근거
- ORD 기록
- ord-437e342210694b3fa36739d83cf07047
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04762848
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