Water → 1-Acetyl-4-(4-hexyloxyphenyl)piperazine

HRID 351546

반응식

HRID 351546 반응식
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C(=O)(O)[O-].[K+].Br[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].O>CS(C)=O.C(OCC)(=O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

7

반응물 4

HCID 962WaterHCID 81011-BromohexaneHCID 516893Potassium BicarbonateHCID 7124411-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

생성물 1

HCID 227132431-Acetyl-4-(4-hexyloxyphenyl)piperazine

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

To a suspension of 1-acetyl-4-(4-hydroxyphenyl) piperazine (20 g) and potassium bicarbonate (12.55 g) in dimethylsulfoxide (200 ml) was added 1-bromohexane (19.12 ml) and stirred for 24 hours at 80° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over is magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-acetyl-4-(4-hexyloxyphenyl)piperazine (14.5 g).

후처리

  1. customdried
  2. filtrationThe magnesium sulfate was filtered off
  3. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-55960f6b25f8486b9db79f648a9dc4ae
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743776B2

연결된 노트

불러오는 중…