1-Chloro-4-(trifluoromethyl)benzene → N,N-Dibutyl-3-(trifluoromethyl)aniline

HRID 355562

반응식

HRID 355562 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[CH2:12]([NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:14][CH3:15].CC(C)([O-])C.[K+].[Br-].[Li+]>C1(C)C=CC=CC=1>[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([N:16]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:12][CH2:13][CH2:14][CH3:15])=[CH:3][CH:4]=1.[F:9][C:8]([F:11])([F:10])[C:5]1[CH:4]=[C:3]([N:16]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:12][CH2:13][CH2:14][CH3:15])[CH:2]=[CH:7][CH:6]=1

참가 물질

7

반응물 4

HCID 73941-Chloro-4-(trifluoromethyl)benzeneHCID 8148DibutylamineHCID 82050Lithium BromideHCID 23665647Potassium tert-butoxide

생성물 2

HCID 18943007N,N-Dibutyl-3-(trifluoromethyl)anilineHCID 18943008N,N-Dibutyl-4-(trifluoromethyl)aniline

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of di-n-butylamine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium (II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenyl-di-n-butylamine and 3-trifluoromethylphenyl-di-n-butylamine in the ratio 7:1 in 58% yield.

출처 및 근거

ORD 기록
ord-78047edeb39c43e8a9f0ce6ab17d7f15
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05831128

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