Potassium Carbonate → 1-(2-Hydrazinylethyl)pyrrolidine

HRID 364182

반응식

HRID 364182 반응식
O.[NH2:2][NH2:3].Cl.Cl[CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.C(=O)([O-])[O-].[K+].[K+].[OH-].[Na+]>O>[NH:2]([CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)[NH2:3]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 816681-(2-Chloroethyl)pyrrolidine hydrochloride

생성물 1

HCID 30315561-(2-Hydrazinylethyl)pyrrolidine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 200 g of 85% hydrazine hydrate, 200 ml of water, 170 g of N-chloroethylpyrrolidine hydrochloride, and 70 g of potassium carbonate was boiled under reflux for seven hours. Sodium hydroxide (390 g) was added and the mixture was extracted with ether. The ethereal extract, dried and distilled, yielded the title compound, bp 107°-111° C. (18.5 mm).

후처리

  1. temperatureunder reflux for seven hours
  2. extractionthe mixture was extracted with ether
  3. extractionThe ethereal extract
  4. customdried
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-16204511989e437e8028f0fb62d2c3b9
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04604390

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