Acetic Acid → 4-Fluorobenzoic Acid

HRID 364688

반응식

HRID 364688 반응식
[F:1][C:2]1[CH:7]=[CH:6]C(C)=[CH:4][CH:3]=1.[C:9]([OH:12])(=[O:11])[CH3:10]>O.O.O.O.C([O-])(=O)C.[Co+2].C([O-])(=O)C.[Br-].[Na+].C([O-])(=O)C.[Na+].O>[F:1][C:2]1[CH:7]=[CH:6][C:10]([C:9]([OH:12])=[O:11])=[CH:4][CH:3]=1

참가 물질

7

반응물 2

HCID 176Acetic AcidHCID 9603p-Fluorotoluene

생성물 1

HCID 99734-Fluorobenzoic Acid수율 86.6%

시약·촉매·용매 4

HCID 61372Cobalt(II) acetate tetrahydrate촉매HCID 253881Sodium Bromide촉매HCID 517045Sodium Acetate촉매HCID 962Water용매

실험 절차

The test described in Example 1 was repeated using 300 g of p-fluorotoluene, 660 g of acetic acid, 132 g of water, 6 g of cobalt acetate tetrahydrate, 5 g of sodium bromide and 5 g of sodium acetate. In a reaction time of 240 minutes, after conventional work-up, 330.5 g of p-fluorobenzoic acid (86.6% of the theory) was obtained, with a purity of 99.9%.

출처 및 근거

ORD 기록
ord-1fce89aec2444e30b48c457d6650fca9
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04605757

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